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Synthesis, Characterisation and In Vitro Biological Evaluation of Novel 3-Chloro-1-(5-ethyl-[1,3,4] thiadiazole-2-yl)-4-phenyl-azetidin-2-one Derivatives

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1TitleTitle of DocumentSynthesis, Characterisation and In Vitro Biological Evaluation of Novel 3-Chloro-1-(5-ethyl-[1,3,4] thiadiazole-2-yl)-4-phenyl-azetidin-2-one Derivatives
2CreatorAuthor's name, affiliation, country SUNIL MAKWANE1*, S. D. SRIVASTAVA1, RAJIV DUA2 and S. K. SRIVASTAVA1
1Synthetic Organic Chemistry Laboratory, Department of Chemistry, School of Chemical Sciences and Technology, Dr. Harisingh Gour University (A Central University), Sagar (M.P), India
2Department of Chemistry, State Forensic Science Laboratory, Department of Home (Police), Government of Madhya Pradesh, Sagar (M.P), India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Thiadiazole, Azetidine, Antimicrobial and Antifungal
4DescriptionAbstract The 1,3,4-thiadiazole molecules are interesting significance in the field of health pharmaceutics and agriculture. Derivatives of 2-amino-5-ethyl-1,3,4-thiadiazole obtained by cyclization from chloroacetyl chloride in the presence of triethyl amine. Schiff base of 2-amino-5-ethyl-1,3,4-thiadiazole on reaction with aromatic aldehydes afforded compound (1). This compound on further reaction with chloroacetyl chloride in the presence of Et3N yielded 3-chloro-1-(5-ethyl-[1,3,4]thiadiazole-2-yl)-4methyl-azetidin-2-ones (2). Antibacterial and antifungal activities were performed on Bacillus subtilis, Escherichia coli and S tyhpi bacteria and Aspergillus niger, Aspergillus flavus and Fusarium oxisporium fungi respectively. Structures of all the synthesized compounds were confirmed using IR, 1H NMR and 13C NMR and MS spectroscopy.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  7 , Number  (4), (2018)
12LanuguageEnglish=en en
13RelationSupp.files
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Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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