Indexing Metadata
A Facile Protocol for Synthesis of Some Novel
2-phenethyl-1H-benzimidazole Derivatives and Screening of In-Vitro Anti-inflammatory and Antimicrobial Activities
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| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | A Facile Protocol for Synthesis of Some Novel
2-phenethyl-1H-benzimidazole Derivatives and Screening of In-Vitro Anti-inflammatory and Antimicrobial Activities
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| 2 | Creator | Author's name, affiliation, country | R.A. SHASTRI* 1 and SATISH B. JADHAV 2
1 P.G.Department of Chemistry, S.B.E.S. College of Science, Aurangabad 431001, Maharashtra, India
2 Departmentof Chemistry, Balbhim Arts, Science and Commerce College, Beed-431122, Maharashtra, India
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| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Phenyl propionic acid, o-phenylenediamine, Benzimidazole, Anti-inflammatory, In-vitro, Antibacterial, Antifungal activity |
| 4 | Description | Abstract | A convenient and efficient method for the preparation of some novel 2-phenethyl-1H- benzimidazole derivatives (4a-h) has been achieved by the condensation of phenyl propionic acids (2a-h) with o-phenylenediamine (3) in POCl3. The advantages of this method is excellent yields, short reaction time, no side reaction and operational simplicity and ease product isolation The structure of all the synthesized compounds were characterized by FT-IR, 1H NMR and MS data. Furthermore, compounds (4a-h) were screened for their antibacterial activity against gram negative (E. coli) and gram positive (B.subtilis) bacteria, antifungal activity against Aspergillusniger and Penicillium chrysogenum and anti-inflammatory activities. Some of the compounds exhibited promising antibacterial, antifungal and anti-inflammatory activities. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 8 , Number (2), (2019) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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