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A Facile Protocol for Synthesis of Some Novel 2-phenethyl-1H-benzimidazole Derivatives and Screening of In-Vitro Anti-inflammatory and Antimicrobial Activities

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1TitleTitle of DocumentA Facile Protocol for Synthesis of Some Novel 2-phenethyl-1H-benzimidazole Derivatives and Screening of In-Vitro Anti-inflammatory and Antimicrobial Activities
2CreatorAuthor's name, affiliation, country R.A. SHASTRI* 1 and SATISH B. JADHAV 2
1 P.G.Department of Chemistry, S.B.E.S. College of Science, Aurangabad 431001, Maharashtra, India
2 Departmentof Chemistry, Balbhim Arts, Science and Commerce College, Beed-431122, Maharashtra, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Phenyl propionic acid, o-phenylenediamine, Benzimidazole, Anti-inflammatory, In-vitro, Antibacterial, Antifungal activity
4DescriptionAbstract A convenient and efficient method for the preparation of some novel 2-phenethyl-1H- benzimidazole derivatives (4a-h) has been achieved by the condensation of phenyl propionic acids (2a-h) with o-phenylenediamine (3) in POCl3. The advantages of this method is excellent yields, short reaction time, no side reaction and operational simplicity and ease product isolation The structure of all the synthesized compounds were characterized by FT-IR, 1H NMR and MS data. Furthermore, compounds (4a-h) were screened for their antibacterial activity against gram negative (E. coli) and gram positive (B.subtilis) bacteria, antifungal activity against Aspergillusniger and Penicillium chrysogenum and anti-inflammatory activities. Some of the compounds exhibited promising antibacterial, antifungal and anti-inflammatory activities.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2019.1566
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  8 , Number  (2), (2019)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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