| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Molecular Docking, Drug-Likeness
Studies and ADMET Prediction of Quinoline
Imines for Antimalarial Activity
|
| 2 | Creator | Author's name, affiliation, country | JAHNABI KALITA, DIPAK CHETIA and MITHUN RUDRAPAL*
Dept. of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh - 786 004, Assam, India |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | P. falciparum, Resistance, Falcipain 2, Quinoline imines, Antimalarial |
| 4 | Description | Abstract | A novel series of quinoline imines were designed by molecular manipulation approach using the principle of rational drug design. Newly designed quinoline imines were screened virtually for antimalarial effectiveness and also for drug-likeness using various in silico tools of drug design. The molecular docking was performed against P. falciparum parasite targeting specific cysteine protease falcipain 2 enzyme. In addition, drug-likeness and ADMET prediction studies were carried out using in silico tools. Our study reports antimalarial potential of novel quinoline imines as drug-like molecules which can be further developed as potent antimalarial agents (falcipain 2 inhibitors) possibly against resistant P. falciparum parasite. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 8 , Number (2), (2019) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
