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Synthesis and Antimicrobial Evaluation of Some Novel 2-(Hydroxyimino)-dihydropyrimidine-5-carboxylic acids

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1TitleTitle of DocumentSynthesis and Antimicrobial Evaluation of Some Novel 2-(Hydroxyimino)-dihydropyrimidine-5-carboxylic acids
2CreatorAuthor's name, affiliation, country R. A. SHASTRI
Post Graduate Department of Chemistry, S.B.E.S. College of Science, Aurangabad- 431001 (Maharashtra), India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Dihydropyrimidinones, Hydroxylamine hydrochloride, Sodium hydroxide
4DescriptionAbstract A series of of 1,2,3,4-tetrahydro-2-(hydroxyimino)-6-methyl/1,6-dimethyl-4-phenyl pyrimidine-5-carboxylic acid (2a-o) were prepared by refluxing ethyl-1,2,3,4-tetrahydro-6- methyl/1,6-dimethyl-2-oxo-4-phenylpyrimidine-5-carboxylate (1a-o) with hydroxylamine hydrochloride in the presence of sodium hydroxide, yielded (2a-o) in excellent yields. The advantages of this method is excellent yields, short reaction time, no side reaction and operational simplicity and ease product isolation The structure of all the synthesized compounds were characterized by FT-IR, 1H NMR and MS data. The compounds 2a-o has been screened for their antimicrobial activity. All the compounds possesses significant to moderate antibacterial activity and promising antifungal activity.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2019.1591
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  8 , Number  (3), (2019)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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