Indexing Metadata
Electrochemical Behavior of Antidepressant
Drug Vilazodone Hydrocholoride and its Determination at F-MWCNT-Nafion/GCE Sensor
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| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Electrochemical Behavior of Antidepressant
Drug Vilazodone Hydrocholoride and its Determination at F-MWCNT-Nafion/GCE Sensor
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| 2 | Creator | Author's name, affiliation, country | MAHADEVA SINGH JAT, KALPANA, K. K. JHANKAL and D. K. SHARMA*
Electrochemical Sensor Research Laboratory, Department of Chemistry,
University of Rajasthan, Jaipur (Rajasthan)-302004, India
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| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Vilazodone hydrochloride, Antidepressant, Cyclic voltammetry, Glassy carbon electrode, Square wave voltammetry |
| 4 | Description | Abstract | A sensitive electroanalytical method for determination of vilazodone hydrocholoride in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at multi-walled carbon nanotubes modified glassy carbon electrode. Vilazodone gave one well-defined oxidation peak at 0.721 potential versus Ag/AgCl reference electrode in citrate buffer of pH 6.5. Oxidation process was irreversible and diffusion controlled. Diffusion coefficients (2.32x10-4 cm2/s and 6.45x10-4cm2/s), surface coverage (4.23x1033mol/cm2 and 98.01x10-3 mol/cm2) and heterogeneous rate constant (0.767s-1 and 1.241s-1) were calculated at both bare GCE and f-MWCNT-nafion modified GCE respectively. Increase values of said parameters proved that f-MWCNT-nafion, doped on bare GCE, positively catalyzed electron transfer between electrode-electrolyte interfaces. Based on CV, CPC and pH studies a oxidation mechanism was proposed involving 2H+/2e-. The proposed square wave voltammetric method shows linearity over the concentration range (0.2x10-5-3.6x10-4M). The achieved limits of detection (LOD) and quantification (LOQ) are 9.6x10-8 g/mL and 3.23x10-7 g/mL respectively. The proposed method was successfully employed for the assay of drug in bulk formulations, human blood and human urine samples. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 8 , Number (4), (2019) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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