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Electrochemical Determination of Cardiovascular Drug Cilnidipine at Glassy Carbon Electrode in Pharmaceutical Formulations

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1TitleTitle of DocumentElectrochemical Determination of Cardiovascular Drug Cilnidipine at Glassy Carbon Electrode in Pharmaceutical Formulations
2CreatorAuthor's name, affiliation, country RAJ KUMAR SHARMA, MAHADEVA SINGH JAT, K. K. JHANKAL and D K SHARMA*
Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur (Rajasthan)-302004, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Cilnidipine, Diffusion controlled, SW cathodic stripping voltammetry, Glassy carbon electrode
4DescriptionAbstract Electrochemical behaviour of cilnidipine at glassy carbon electrode was investigated using cyclic, square wave cathodic adsorptive stripping (SW-CAdS) and differential pulse cathodic adsorptive stripping (DP-CAdS) voltammetry under different experimental conditions. The voltammetric peak current and potential for the reduction of cilnidipine were analysed at different pH, scan rate and concentration. The voltammograms exhibited irreversible reduction of cilnidipine in B R buffer of pH 5.5. Cilnidipine gave one well-defined reduction peak at -0.821 potential versus Ag/AgCl reference electrode in BR buffer of pH 5.5. Reduction process was irreversible and diffusion controlled. Diffusion coefficients (7.45x10-4 cm2/s and 6.45x10-4 cm2/s), surface coverage (4.23x10-3mol/cm2 and 98.01x10-3mol/cm2) and heterogeneous rate constant (1.25x102s-1) were calculated at bare GCE respectively. Based on CV, CPC and pH studies a reduction mechanism was proposed involving 6H+/6e-. The proposed square wave voltammetric method shows linearity over the concentration range (4.21x10-6-9.71x10-3 M) The achieved limits of detection (LOD) and quantification (LOQ) are 5.44x10-8 g/mL and 1.52x10-7g/mL respectively.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2019.1597
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  8 , Number  (3), (2019)
12LanuguageEnglish=en en
13RelationSupp.files
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Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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