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Development of New Visible Spectrophotometric Methods for Quantitative Determination of Almotriptan Malate Using Quinones as Chromogenic Reagents

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1TitleTitle of DocumentDevelopment of New Visible Spectrophotometric Methods for Quantitative Determination of Almotriptan Malate Using Quinones as Chromogenic Reagents
2CreatorAuthor's name, affiliation, country M. SYAM BAB*a, U. VIPLAVA PRASADa and B. KALYANA RAMUb
aDepartment of Organic Chemistry & Analysis of Foods Drugs & Water Laboratories, School of Chemistry, Andhra University, Visakhapatnam-530003, Andhra Pradesh, India
bDepartment of Chemistry, Maharajah’s College (Aided & Autonomous), Vizianagaram-535002 (AP), India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Anti migraine, Quinones, Acetaldehyde, Assay, Chloranilic acid, Spectrophotometer, Validation
4DescriptionAbstract Two simple, sensitive and cost effective visible spectrophotometric methods (M1-M2) were developed for the estimation of almotriptan malate in bulk and dosage forms. The first method (M1) is based on the formation of radical anion with the involvement of basic nitrogen in drug (free base form) (n-donor) and chloranilic acid (DHQ) (p-acceptor). The purple colored product exhibits absorption maximum at 544 nm in methanol. The second method (M2) is based on the interaction of N-alkyl vinyl amine formed from the condensation of the free secondary amine group in the drug and acetaldehyde with p-chloranil (TQ) to give vinyl amino substituted quinone. The blue colored product exhibits an absorption maximum at 660 nm in dioxane. Beer’s law obeyed in the concentration range of 25-125 µg/mL and 20 - 60 µg/mL for method M1 and M2 respectively. Commercially available tablets were analyzed; the results obtained by the proposed methods were in good agreement with the labeled amounts. These methods offer the advantages of rapidity, simplicity, sensitivity and normal cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2012.181
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  1 , Number  (2), (2012)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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