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Benzodioxole and 1,2,4-Oxadiazole Associated 1,2,3-Triazoles: Synthesis, Characterization and Evaluation as Antibacterial Agents

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1TitleTitle of DocumentBenzodioxole and 1,2,4-Oxadiazole Associated 1,2,3-Triazoles: Synthesis, Characterization and Evaluation as Antibacterial Agents
2CreatorAuthor's name, affiliation, country Y. PARTHASARADHI and T. SAVITHA JYOSTNA*
Department of Chemistry, Kakatiya University, Warangal-506009, Telangana, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords 1,2,3-Triazoles, Benzodioxole, 1,2,4-Oxadiazole, Synthesis, Characterization
4DescriptionAbstract A novel series of 1-((3-((benzo[d][1,3]dioxol-6-yl)methyl)-1,2,4-oxadiazole-5-yl)methyl-4-phenyl-1H-1,2,3-triazole and its derivatives (5a-f) has been synthesized in good yields by cyclization of 5-(azidomethyl)-3-((benzo[d][1,3]dioxol-6-yl)methyl)-1,2,4-oxadiazole(4) by using 3,4-(methylenedioxy) phenylacetonitrile (1) as starting compound and (Z)-2-(Benzo[d][1,3]dioxol-6-yl)- N- hydroxyacetamidine (2) and 3-((benzo[d][1,3]dioxol-6-yl)methyl)-5-(chloromethyl)-1,2,4-oxadiazole (3) as intermediates. The target compounds have been purified and characterized by IR, 1H and 13C NMR, Mass spectral data and elemental analysis. Further, the title compounds were evaluated for their preliminary in vitro antibacterial activity against two representative gram-positive bacteria like Bacillus subtilisand Staphylococcus aureus and two gram-negative bacteria such as Escherichia coli and Salmonella typhi. All tested compounds exhibited moderate to good activity with a degree of modification.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2019.20190003
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  8 , Number  (4), (2019)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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