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Synthesis and Antimicrobial Activity of Some Novel Chalcones of 3-Acetyl Pyridine and their Pyrimidine Derivatives

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1TitleTitle of DocumentSynthesis and Antimicrobial Activity of Some Novel Chalcones of 3-Acetyl Pyridine and their Pyrimidine Derivatives
2CreatorAuthor's name, affiliation, country M.V.JYOTHIa*, Y. RAJENDRA PRASADb, P. VENKATESHc and M. SURESHREDDYa
aDepartment of Pharmaceutical Chemistry, Raghavendra Institute of Pharmaceutical Education and Research, K.R.Palli Cross, Anantapur-515 721, (A.P), India
bUniversity College of Pharmaceutical Sciences, Andhra University,
Visakhapatnam-530 003, (A.P), India
cNational Institute of Pharmaceutical Education and Research, Balanagar,
Hyderabad - 500037 (A.P), India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Chalcones, Synthesis, Antimicrobial activity
4DescriptionAbstract Chalcones afford a facile route of access to many of the heterocyclic systems containing oxygen and nitrogen. An attempt is therefore made to synthesize chalcones from 3-acetylpyridine by reaction with either aromatic or heteroaromatic aldehyde using Claisen-Schmidt condensation. The resulting chalcones after purification and characterization by physical and spectral methods have been successfully converted into substituted pyrimidines by reaction with guanidine hydrochloride. All these compounds were characterized by means of their IR, 1H NMR, 13C NMR and mass spectral data. These compounds were evaluated for antimicrobial activities by cup plate method.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2012.223
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  1 , Number  (3), (2012)
12LanuguageEnglish=en en
13RelationSupp.files
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