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New Derivative Spectrophotometric Methods for the Determination of Fluoxetine - An Antidepressant Drug

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1TitleTitle of DocumentNew Derivative Spectrophotometric Methods for the Determination of Fluoxetine - An Antidepressant Drug
2CreatorAuthor's name, affiliation, country M. MATHRUSRI ANNAPURNA* and DEBI PRASAD PRADHAN
*Department of Pharmaceutical Analysis and Quality Assurance,
GITAM Institute of Pharmacy, GITAM University, Visakhaptanam, India
Department of Pharmaceutical Analysis and Quality Assurance,
Roland Institute of Pharmaceutical Sciences, Berhampur-760010, Orissa, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Fluoxetine HCl, Derivative spectrophotometry, Antidepressant drug
4DescriptionAbstract Fluoxetine is an antidepressant of the selective serotonin reuptake inhibitor class. Two simple, rapid and sensitive first and second derivative spectrophotometric methods are developed for the determination of fluoxetine (FLX) in pharmaceutical dosage forms (capsules). The absorption minima was chosen (at 235 nm) in first order (Method A) and amplitude (229-238.5 nm) was selected in second order derivative spectral calculations. Fluoxetine follows Beer’s law in the concentration range of 1-60 µg mL-1 (r2= 0.999) in first order as well as in second order (r2 = 0.9994) derivative spectroscopy respectively. The proposed methods can be successfully applied for the determination of Fluoxetine in commercial brands of pharmaceutical formulations. No interferences were observed from the common excipients in the formulations. The methods were validated according to ICH guidelines.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2012.225
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  1 , Number  (3), (2012)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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