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New Derivative Spectrophotometric Methods for the Determination of Zolpidem Tartrate in Pharmaceutical Dosage Forms

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1TitleTitle of DocumentNew Derivative Spectrophotometric Methods for the Determination of Zolpidem Tartrate in Pharmaceutical Dosage Forms
2CreatorAuthor's name, affiliation, country M. MATHRUSRI ANNAPURNA*, B. SAI PAVAN KUMAR, J. RAJ PRAKASH and B. VENKATESH
Department of Pharmaceutical Analysis & Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Zolpidem Tartrate, Derivative spectrophotometry, Validation
4DescriptionAbstract Two simple, rapid and sensitive first derivative spectrophotometric methods were developed for the determination of zolpidem tartrate in pharmaceutical formulations in phosphate buffer pH 8.0 and borate buffer pH 9.0. Beer’s law was obeyed in a concentration range of 1-30 µg/mL in phosphate buffer pH 8.0 and borate buffer pH 9.0 respectively with correlation coefficient of r2 =0.999 in both the methods. The linear regression equations are found to be y=0.008x+0.001 and y = 0.0094x + 0.0033 in phosphate and borate buffer respectively. The %RSD for intra-day and inter-day precision studies were found to be 0.23 and 0.56 in phosphate buffer pH 8.0 and 0.63 and 0.68 in borate buffer pH 9.0 respectively which is less than 2.0 indicating that the methods are precise. The %RSD in accuracy studies was also found to be less than 2.0. The proposed methods are suitable for the determination of zolpidem tartrate in pharmaceutical formulations. No interferences were observed from the excipients in the formulations. The methods were validated according to ICH guidelines.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2012.226
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  1 , Number  (3), (2012)
12LanuguageEnglish=en en
13RelationSupp.files
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