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Novel Piperazinyl-Quinazoline-4-one Analogs: Design, Synthesis and Evaluation of In Vitro Biological Activity

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1TitleTitle of DocumentNovel Piperazinyl-Quinazoline-4-one Analogs: Design, Synthesis and Evaluation of In Vitro Biological Activity
2CreatorAuthor's name, affiliation, country K. N. MYANGAR*, T. N. AKHAJA, D. R. NAIK and J. P. RAVAL
Department of Pharmaceutical Chemistry, Ashok & Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences (ARIBAS), ADIT Campus, New Vallabh Vidhyanagar 388 121, Dist: Anand, Gujarat, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Piperazine, 2-Chloromethyl-3-(N-isonicotinamide-yl)-4Hquinazolinone, Antitubercular activity
4DescriptionAbstract A series of novel 2-[4-substituted-piperazinyl-methyl]-3-[N-isonicotinamide-yl]-quinazoline-4-one (4a-l) were designed, synthesized, characterized and evaluated for in vitro antitubercular, antibacterial and antifungal activity. Compounds 4f, 4h and 4l exhibited excellent antitubercular activity against mycobacterium tuberculosis H37Rv.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2012.243
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  1 , Number  (3), (2012)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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