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A Simple Spectrophotometric Determination of Rebeprazole in Pharmaceutical Preparations

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1TitleTitle of DocumentA Simple Spectrophotometric Determination of Rebeprazole in Pharmaceutical Preparations
2CreatorAuthor's name, affiliation, country RAMESH KUMAR M, SREENIVASULU REDDY T and PRABHAVATHI K
Department of Chemistry, The Adoni Arts and Science College, Adoni, Kurnool (Dt), A.P, India
Department of Chemistry, S.K. University, Anantapur (Dt), A.P, India
Department of Chemistry, S.B.S.Y.M. Degree College, Kurnool (Dt), A.P, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Rabeprazole, 2, 3-Dichloro-5, 6-dicyano-p-benzoquinone, Pharmaceutical formulations, DDQ, Determinations
4DescriptionAbstract A simple, sensitive spectrophotometric method was developed for the determination of rabeprazole in pure form and for pharmaceutical formulations. In this method 2,3-dichloro-5, 6-dicyano-p-benzoquinone (DDQ) was utilized for determination of rabeprazole forming charge transfer complex with maximum absorbance at λmax 460 nm. Variables affecting the reaction were studied and optimized. Beer’s law was obeyed in concentration range 20-100 µg/mL for rabeprazole. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies. The proposed method is simple, rapid and validated and can be used successfully for routine analysis of rabeprazole in a pure and tablet dosage form.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2013.283
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (1), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
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15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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