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Design, Synthesis and Pharmacological Evaluation of New Series of Pyrazolines Based Thiazolidin-4-one Derivatives

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1TitleTitle of DocumentDesign, Synthesis and Pharmacological Evaluation of New Series of Pyrazolines Based Thiazolidin-4-one Derivatives
2CreatorAuthor's name, affiliation, country PINKA PATEL, DEEPA GOR and P. S. PATEL
K. K Shah Jarodwala Maninagar Science College, Ahmedabad-8, India
Department of Chemistry, Sheth L. H. Science College, Mansa-382845, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Synthesis, Pyrazoline, Chalcones, Schiff base, DMSO, Antimicrobial activity
4DescriptionAbstract We have prepared 2-{4-[2-{5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-pyrazol-1-yl}-2-oxoethoxy]phenyl}-3-(substituted phenyl)-1,3-thiazolidin-4-one form N-[{4-[2-{5-(4-chloro-phenyl)-3-(4-methoxyphenyl)-4,5-dihydro-pyrazol-1-yl}-2-oxoethoxy]phenyl}methylene] substituted aniline and thioglycolic acid. Compound having an excellent properties regarding as per as anti cancer and HIV as compared to this compound. Physical properties of pure crystallized substance of 2-{4-[2-{5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-pyrazol-1-yl}-2-oxoethoxy]phenyl}-3-(subs-tituted-phenyl)-1,3-thiazolidin-4-one substituted aniline like M.P elementary analysis and spectral data of compound and such as IR and NMR will be evaluated and confirm the structure of compound. All the synthesized products were evaluated for their antimicrobial activity. All the compounds were tested for their antibacterial and antifungal activities by broth dilution method.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2013.301
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (4), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
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