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Synthesis, Characterization and Testing of Biological Activity of Some Novel Chalcones Derivatives of Coumarin

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1TitleTitle of DocumentSynthesis, Characterization and Testing of Biological Activity of Some Novel Chalcones Derivatives of Coumarin
2CreatorAuthor's name, affiliation, country HARSHAL A. DESHPANDE, HIMANI N. CHOPDE, CHANDRASHEKAR P. PANDHURNEKAR and RAMESHKUMAR J. BATRA
Department of Applied Chemistry, I. T. M. College of Engineering, Kamptee, Dist.
Nagpur-441 002, India
Department of Applied Chemistry, G. H. Raisoni Academy of Engineering and Technology, Nagpur-440 016, India
Department of Applied Chemistry, Shri Ramdeobaba College of Engineering and Management, Nagpur-440 013, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Chalcone derivatives, Coumarins, Anti-bacterial activity
4DescriptionAbstract In the present communication, we herein report the synthesis of some novel derivatives of coumarin i.e. 3-((2E)-(3-(2-hydroxy-5-((aryl)diazenyl)phenyl)acryloyl)-2H-chromen-2-one (2a-2g). Various aromatic amines and salicylaldehyde in the presence of sodium nitrite and conc. HCl yielded 2-hydroxy-5-((aryl)diazenyl)benzaldehyde (1a-1g). A series of 3-((2E)-(3-(2-hydroxy-5-((aryl)diazenyl) phenyl)acryloyl)-2H-chromen-2-one were synthesized by the reaction of 2-hydroxy-5-((aryl)diazenyl) benzaldehyde and coumarin in presence of ethanol and piperidine. Different analytical techniques such as elemental analysis, IR spectra, 1H NMR spectra and mass spectra were used to elucidate the structures of all newly synthesized compounds (1a-1g and 2a-2g). The anti-bacterial and anti-fungal activity of newly synthesized chalcone derivatives (2a-2g) were evaluated against different bacterial and fungal stains. Some of these compounds showed promising activity against different stains.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2013.317
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (2), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
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