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Synthesis and In Vitro Antioxidant Evaluation of Some Indole-2-carboxylic Acid-Aryl Amine Conjugates

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1TitleTitle of DocumentSynthesis and In Vitro Antioxidant Evaluation of Some Indole-2-carboxylic Acid-Aryl Amine Conjugates
2CreatorAuthor's name, affiliation, country NAGARAJA NAIK, V. SHARATH, H. VIJAY KUMAR and H. SWETHA
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570006, Karnataka, India
Department of Organic Chemistry, Indian Institute of Science, Banglore-570012, Karnataka, India
Plantation Products, Spices & Flavour Technology, Central Food Technological and Research Institute, Mysore-570006, Karnataka, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Free radicals, Antioxidant activity, Indole-2-carboxylic acid, Aryl amines
4DescriptionAbstract A simple and efficient protocol for the synthesis of novel indole-2-carboxylic acid analogues having aryl amine moieties (2a-k) has been described. The synthesized compounds were characterized by spectroscopic techniques (IR, 1H NMR, 13C NMR and MS-EI) and further screened for their antioxidant activity by using various in vitro assays such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS+) radical scavenging activity, ferric reducing antioxidant power, cupric ion reducing ability method and phosphomolybdate method. In all the antioxidant assays performed, compounds 2b, 2d, 2e and 2f showed promising antioxidant activity. Whereas, compound 2c displayed potent antioxidant activity.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2013.331
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (1), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
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