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Synthesis and Biological Activities of 3-Alkyl-5-substituted 1,2,4-Triazole Derivatives

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1TitleTitle of DocumentSynthesis and Biological Activities of 3-Alkyl-5-substituted 1,2,4-Triazole Derivatives
2CreatorAuthor's name, affiliation, country N. U. SIDDIQUI, MOHD. ASLAM and RAJESH KUMAR
Department of Chemistry, G.F. (P.G.) College, Shahjahanpur (U.P.)-242001, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Alkyl-substituted-1,2,4-triazoles, Antimicrobial activity, Synthesis
4DescriptionAbstract Starting from the ester (methyl/ethyl) with hydrazine hydrate, a variety of new compounds 3-alkyl-5-(3’5’dimethyl-1-H-pyrazole-1!-yl)-1,2,4,-triazole (5a & 5b); 3-alkyl-5-(N-pyrazolidine)-amino-1,2,4-triazole (6a & 6b) and 2-alkyl-4-mercapto (1,2,4)-triazole (3,4-b) 1,3,4-triazole (7a & 7b) have been synthesized. All proposed structures were supported by IR, 1H-NMR, 13C NMR and elemental analysis. These newly synthesized compounds (5a & 5b-7a & 7b) have been screened for their antibacterial activity on E. coli, P. aeruginosa, S. aureus and
S. pyrogenes
and antifungal activity on C. albicans, A. niger and A. clavatus.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (2), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
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Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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