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Synthesis and Characterization of Substituted Phenyl Azetidines as Potential Antimicrobial Agents

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1TitleTitle of DocumentSynthesis and Characterization of Substituted Phenyl Azetidines as Potential Antimicrobial Agents
2CreatorAuthor's name, affiliation, country K. DORASWAMY and P. VENKATA RAMANA
Department of Chemistry, Sri Krishnadevaraya University, Anantapur- 515 003, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Substituted azetidines, Borane reduction, Antimicrobial activity
4DescriptionAbstract The reaction of 2-(4-bromo phenyl) methyl cyanide (1a) with ethylchloroformate in the presence of n-butyl lithium gave ethyl-2-(4-bromo phenyl)-2-cyano acetate (2a). 2a on reduction with sodium borohydride yields 3-amino-2-(4-bromo phenyl) propan-1-ol (3a). Compound 3a on further reaction with tert butyloxy anhydride in presence of triethylamine afford tert-butyl-2-(4-bromo phenyl)-3-hydroxy propyl carbamate (4a). 4a on treatment with tosyl chloride gave 2-(4-bromo phenyl)-3-(tertiarybutyloxy carbonyl amino)-propan-1-ol-(4-toluene sulphonate) (5a). Compound 5a on cyclization followed by hydrolysis gave 3-(4-bromo phenyl) azetidine (7a). Compounds 2b-2e, 3b-3e, 4b-4e, 5b-5e, 6b-6e and 7b-e were synthesized by a similar method. The compounds are characterized by elemental analysis, IR, 1H NMR and Mass spectral analysis and screened for antimicrobial activity.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2013.377
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (2), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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