| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Synthesis and Characterization of Substituted Phenyl Azetidines as Potential Antimicrobial Agents |
| 2 | Creator | Author's name, affiliation, country | K. DORASWAMY and P. VENKATA RAMANA
Department of Chemistry, Sri Krishnadevaraya University, Anantapur- 515 003, India |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Substituted azetidines, Borane reduction, Antimicrobial activity |
| 4 | Description | Abstract | The reaction of 2-(4-bromo phenyl) methyl cyanide (1a) with ethylchloroformate in the presence of n-butyl lithium gave ethyl-2-(4-bromo phenyl)-2-cyano acetate (2a). 2a on reduction with sodium borohydride yields 3-amino-2-(4-bromo phenyl) propan-1-ol (3a). Compound 3a on further reaction with tert butyloxy anhydride in presence of triethylamine afford tert-butyl-2-(4-bromo phenyl)-3-hydroxy propyl carbamate (4a). 4a on treatment with tosyl chloride gave 2-(4-bromo phenyl)-3-(tertiarybutyloxy carbonyl amino)-propan-1-ol-(4-toluene sulphonate) (5a). Compound 5a on cyclization followed by hydrolysis gave 3-(4-bromo phenyl) azetidine (7a). Compounds 2b-2e, 3b-3e, 4b-4e, 5b-5e, 6b-6e and 7b-e were synthesized by a similar method. The compounds are characterized by elemental analysis, IR, 1H NMR and Mass spectral analysis and screened for antimicrobial activity. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 2 , Number (2), (2013) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
