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Synthesis, Characterizationand Antibacterial Activity of Quaternary Ammonium Compounds Bearing Mixed N-Substituted Groups

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1TitleTitle of DocumentSynthesis, Characterizationand Antibacterial Activity of Quaternary Ammonium Compounds Bearing Mixed N-Substituted Groups
2CreatorAuthor's name, affiliation, country SOFIANE DAOUDI, ADIL A. OTHMAN, TAHAR BENAISSA and ZAHRA OULD KADA
Laboratory of Bioactive Organic Chemistry, Department of Chemistry, Faculty of Sciences, University of Sciences and Technology of Oran -Mohamed Boudiaf, P.O.Box 1505 El-M’naouer, Oran 31003, Algeria
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Alkyl and cycloalkyl bromides, Benzyl bromides, Dialkylaminomethyl acrylate bromides, Quaternary ammonium compounds, Antibacterial activity
4DescriptionAbstract Sixteen quaternary ammonium bromides [QAB]4(a-d)-7(a-d)bearing mixed N-branches were synthesized by treating n-butyl 2a, cyclohexyl 2b, 2,3,4,6-tetra-O-acetyl – D- glucosyl 2c and cholesteryl 2d bromides, separately with n-butyl amine 3a, benzyl amine 3b, N,N-dimethyl amino ethyl-2- methyl acrylate 3c and
N,N-diethyl amino ethyl-2- methyl acrylate 3d. N,N-Diphenyl amine 3e failed to react with any bromides within the scope of this work. The synthesized bromides and QAB were characterized by FT-IR, 1H NMR and 13C NMR. All compounds were tested for their activity against some gram-positive and gram-negative bacteria and some of them exhibited significant antibacterial activities.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.378
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (1), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
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