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New RP-UFLC Method for Estimation of Xanthinol Nicotinate in Pharmaceutical Dosage Form

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1TitleTitle of DocumentNew RP-UFLC Method for Estimation of Xanthinol Nicotinate in Pharmaceutical Dosage Form
2CreatorAuthor's name, affiliation, country SAGAR SUMAN PANDA, B.V.V. RAVI KUMAR, PINKAL KUMAR PATEL and
JNYANARANJAN PANDA
Department of Pharmaceutical Analysis and Quality Assurance, Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Xanthinol, RP-UFLC, Validation, Stability, Nicotinic acid
4DescriptionAbstract A novel, accurate and precise RP-UFLC method for determination of xanthinol nicotinate has been developed and validated. Separation was achieved on an Enable C18G column (250 mm 4.6 mm i.d., 5 m) using acetonitrile: 10 mM TBAHS (40:60, v/v) as mobile phase at a flow rate of 0.8 mL/min and PDA detection at 274 nm. Linearity was observed in the concentration range of 1.0-60 g/mL (r2=0.999). The method was validated for accuracy, precision, stability, specificity, robustness and system suitability. Forced degradation was performed by using HCl, NaOH, H2O2, thermal and UV radiation. The method was used successfully for the determination of xanthinol nicotinate in tablet dosage form.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2013.379
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (2), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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