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Direct and Derivative Spectrophotometric Determination of
Zn(II) in Pharmaceuticals

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1TitleTitle of DocumentDirect and Derivative Spectrophotometric Determination of
Zn(II) in Pharmaceuticals
2CreatorAuthor's name, affiliation, country D. SREE VANI, K. SARA SUBUDHI, S. SHIVARAMAIAH and K. ASHOK RAO
Research laboratories, Department of chemistry, V. R. Group of Institutions, Nellore, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Zinc determination, Direct and derivative spectrophotometry, DADHP
4DescriptionAbstract Heterocyclic compound diamino and dihydroxy- pyramidine was synthesized and proposed as chelating agent for the determination of trace amounts of zinc. Zinc(II) forms the ripen-mango-colour complex with DADHP (Diamino dihydroxypyrimidine) in 1:3 stoichiometric ratio at pH-6 in acetic acid and sodium acetate buffer in the presence of pyrideniumchloride as salting out agent. The maximum absorbance is observed at 480 nm. The Beer's law is obeyed in the range of 1-6 µg. The molar absorptivity (ε) and Sandell’s sensitivity of the complex is 0.1484x104 L mol-1 cm-1 and 0.04545 µg cm-1 respectively. The method was successfully applied for the quantification of Zn(II) in pharmaceutical multi vitamin preparations in the presence of other trace elements. The statistical data evaluated reveals the sensitivity and accuracy of the method than the other methods reported.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (2), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
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15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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