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Synthesis, Structural Study and Biological Activity of Bridgehead Nitrogen Containing Triazolo-thiadiazine Derivatives

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1TitleTitle of DocumentSynthesis, Structural Study and Biological Activity of Bridgehead Nitrogen Containing Triazolo-thiadiazine Derivatives
2CreatorAuthor's name, affiliation, country PRADIP P. DEOHATE
P. G. Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola-444001, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Synthesis, Biological activity, Triazolo-thiadiazines
4DescriptionAbstract A facile synthesis of 6,7-di-[substituted]-phenyl-3-pyridin-4-yl-5H-[1,2,4]-triazolo-[3,4-b]-[1,3,4]-thiadiazines have been carried out by reacting 4-amino-3-mercapto-5-pyridin-4-yl-4H-[1,2,4]-triazole with substituted benzoins in presence of potassium hydroxide. The required 4-amino-3-mercapto-5-pyridin-4-yl-4H-[1,2,4]-triazole was synthesized by reacting isoniazide with carbon-disulphide and potassium hydroxide followed by the addition of hydrazine hydrate. The acetylation of triazolo-thiadiazines afforded monoacetyl derivatives. The constitution of synthesized compounds have been delineated on the basis of chemical transformation, elemental analysis, equivalent weight determination and IR, 1H NMR spectral studies. The title compounds have been assayed for their biological activity against gram-positive as well as gram-negative microorgansms.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2013.397
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (2), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
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Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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