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Synthesis, Structural Study and Antimicrobial Screening of Substituted Bis-benzothiazole Derivatives

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1TitleTitle of DocumentSynthesis, Structural Study and Antimicrobial Screening of Substituted Bis-benzothiazole Derivatives
2CreatorAuthor's name, affiliation, country PRADIP P. DEOHATE
P. G. Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola-444001, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Synthesis, Structural study, Antimicrobial screening, Bis-benzothiazoles
4DescriptionAbstract A series of {4-[4-(6-substituted-benzothiazol-2-yl-amino)-3-carboxy-benzyl]-2-carboxy-phenyl}-6-substituted-benzothiazol-2-yl-amines have been synthesized by oxidative cyclization of 1-{4-[4-(3-aryl thiocarbamido)-3-carboxy-benzyl]-2-carboxy-phenyl}-3-aryl thiocarbamides using the solution of bromine in chloroform followed by the basification with dilute ammonium hydroxide solution. Initially 1-{4-[4-(3-aryl thiocarbamido)-3-carboxy-benzyl]-2-carboxy-phenyl}-3-aryl thio-carbamides were prepared by the interaction of different aryl isothiocyanates with 4,4-methylene-bis-(anthranilic acid). The latter was obtained by treating the mixture of anthranilic acid and concentrated hydrochloric acid with 3% aqueous formaldehyde followed by neutralization with sodium hydroxide. The acetylation of bis-benzothiazoles afforded di-acetyl derivatives. The structures of synthesized compounds have been established on the basis of chemical transformation, elemental analysis, equivalent weight determination and IR, 1H NMR spectral studies. The title compounds have been assayed for their biological activity against gram-positive as well as gram-negative microorganisms.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2013.414
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (2), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
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