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Extractive Visible Spectrophotometric Determination of Lamotrigine in Pure and Pharmaceutical Formulations

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1TitleTitle of DocumentExtractive Visible Spectrophotometric Determination of Lamotrigine in Pure and Pharmaceutical Formulations
2CreatorAuthor's name, affiliation, country N. V. V. NAGA MALLESWARA RAO, S. PULLA REDDY, S. V. M. VARDHAN and C. RAMBABU*
Department of Chemistry, Acharya Nagarjuna University, Guntur, A.P, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Lamotrigine (LMT), Tropaeolineo-oo (TPooo), Alizarine Red S (ARS)
4DescriptionAbstract wo simple, sensitive, accurate and economical spectrophotometric methods (A & B) for the determination of lamotrigine (LMT) in pure and pharmaceutical formulations (tablets) are described in the present work. Method A is based on the formation of coloured ion-association complex between lamotrigine and tropaeolineo-oo (TPooo) with absorption maximum at 485 nm and obeys Beer’s law in the concentration range of 5-25 μg/mL. Formation of ion-association complex between lamotrigine and alizarine Red S (ARS) to yield a coloured chromogen exhibiting absorption maximum at 440 nm (Method B) obeying Beer’s law in the concentration range of 5-25 μg/mL forms the basis of Method B. The two methods have been validated statistically through recovery studies. The results are compared with those obtained using UV spectrophotometric method (Reference method) in chloroform at 260 nm.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2013.422
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (3), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
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15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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