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Determination of Emtricitabine by Derivative Spectrophotometric Method in Pharmaceutical Dosage Forms

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1TitleTitle of DocumentDetermination of Emtricitabine by Derivative Spectrophotometric Method in Pharmaceutical Dosage Forms
2CreatorAuthor's name, affiliation, country A. NARENDRA*, D. DEEPIKA and M. MATHRUSRI ANNAPURNA
Micro Advanced Research Centre, Bangalore, Karnataka, India
Vijaya Institue of Pharmaceutical Sciences for Women, Vijayawada, A.P, India
GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, A.P., India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Emtricitabine, Derivative spectroscopy, Area under curve
4DescriptionAbstract Three simple, precise and accurate spectrophotometric methods have been developed for the estimation of emtricitabine in bulk and pharmaceutical formulations. Emtricitabine exhibits maximum absorbance at
282.0 nm in method A. The amplitude shows at 269.0-298.0 nm in method B and method C is based on calculation of area under curve (AUC) in the wavelength region of 272.0-292.0 nm. The drug obeys the Beer-Lambertís law in the concentration range of 1.0-100 μg/mL in all three methods. The methods were validated by following the analytical performance parameters suggested by the International Conference on Harmonization. All validation parameters were within the acceptable range. The developed methods were successfully applied to estimate the amount of emtricitabine in bulk and pharmaceutical dosage forms.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2013.486
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (3), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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