| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Design and Synthesis of Novel 2-Trichloromethyl-4-Substituted Quinazoline Derivatives as
Anti-tubercular Agents |
| 2 | Creator | Author's name, affiliation, country | MANEESH KUMAR SRIVASTAV and S. M. SHANTAKUMAR*
Department of Pharmaceutical Chemistry, V. L. College of Pharmacy, Raichur-584103, Karnataka, India |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Anti-tubercular activity, 2-Trichloromethyl quinazoline, Acetylation |
| 4 | Description | Abstract | In order to produce a new lead for anti-tubercular drug a series of novel 2-trichloromethyl quinazoline derivatives bearing substituted secondary amine group at the 4th position were designed, synthesized and evaluated for their in vitro anti-tubercular activity against bacterial strain of M. tuberculosis H37Rv ATCC (American Type Culture Collection) by Alamar Blue assay method (MABA). The targeted molecules (4a-j) were synthesized from 4-chloro-2-(trichloromethyl) quinazoline and substituted secondary amine in dichloromethane using catalytic amount of KI, under reflux for 15-18 h. All the targeted compounds are new chemical entities and obtained in satisfactory yields and the structure of the synthesized compounds are in agreement with spectral data. Compound 4a and 4f exhibited potent anti-tubercular activity against bacterial strain of M. tuberculosis H37Rv, with MIC value 6.25 μG. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 2 , Number (3), (2013) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
