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New Spectrophotometric Methods for the Quantitative Analysis of Fluorometholone in Ophthalmic Suspensions

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1TitleTitle of DocumentNew Spectrophotometric Methods for the Quantitative Analysis of Fluorometholone in Ophthalmic Suspensions
2CreatorAuthor's name, affiliation, country A.NARENDRA, D.DEEPIKA and M.MATHRUSRI ANNAPURNA
Micro Advanced Research Centre, Bangalore, Karnataka, India
VijayaInstitue of Pharmaceutical Sciences for women, Vijayawada, A.P, India
GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, A.P., India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Fluorometholone, Eye drops, Validation
4DescriptionAbstract Two simple, rapid and sensitive spectrophotometric methods were developed for the determination of Fluorometholone in pharmaceutical formulations in methanol (Method A) and Octane sulfonic acid buffer (pH 3.0) (Method B). Beer’s law was obeyed over the concentration range 0.1-80 µg/mL in both methods. The linear regression equations were found to be y = 0.040x + 0.005 and y = 0.040x - 0.013 in Method A and B respectively. The % RSD was found to be 0.76 and 0.97 in Method A as well as 0.58 and 0.49 in Method B for intra-day and inter-day precision studies. The % RSD in accuracy studies was also found to be less than 2.0. The proposed methods are simple and suitable for the determination of Fluorometholone in pharmaceutical formulations. No interferences were observed from the excipients in the formulations. The methods were validated according to ICH guidelines.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.492
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (1), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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