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Synthesis and Characterization of Specified Impurities of Aceclofenac

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1TitleTitle of DocumentSynthesis and Characterization of Specified Impurities of Aceclofenac
2CreatorAuthor's name, affiliation, country P. L. SOMASHEKAR*, P. N. SANJAY PAI and GOPALKRISHNA RAO
Department of Quality Assurance, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Hosur Road, Bangalore -560 027, India
Department of Pharmaceutical Chemistry, Goa College of Pharmacy, 18th June Road, Panaji, Goa- 403 001, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Aceclofenac, Impurity, Synthesis, Characterization
4DescriptionAbstract The present study aimed at synthesizing the process related potential impurities of aceclofenac. Aceclofenac is an orally administered phenyl acetic acid derivative with effects on a variety of inflammatory mediators. Process related impurities of aceclofenac listed in British Pharmacopoeia have been synthesized by modified methods and characterized by FT IR, MS and 1H NMR data. Impurity A: [2-[(2,6-dichlorophenyl)amino]phenyl]acetic acid (diclofenac) was synthesized by acid hydrolysis of diclofenac sodium; Impurity B: methyl [2-[(2,6-dichlorophenyl) amino] phenyl]acetate (methyl ester of diclofenac); Impurity C:Ethyl [2-[(2,6-dichlorophenyl) amino] phenyl]acetate (ethyl ester of diclofenac); Impurity D: methyl [[[2-[(2,6-dichlorophenyl) amino] phenyl] acetyl] oxy]acetate (methyl ester of aceclofenac) and Impurity E: ethyl [[[2-[(2,6-dichlorophenyl) amino]phenyl] acetyl] oxy]acetate (ethyl ester of aceclofenac) were sythesized by simple and convenient direct methylation and ethylation of diclofenac and aceclofenac respectively instead of tedious esterification process. Impurity F: benzyl [[[2-[(2,6-dichlorophenyl) amino] phenyl] acetyl] oxy] acetate (benzyl ester of aceclofenac) was synthesized by condensation of diclofenac sodium with benzylbromoacetate. Impurity I:1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indol-2-one was synthesized by acid cyclization of diclofenac. The present study has provided an efficient method for synthesis of process related aceclofenac impurities.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2013.496
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (3), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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