Indexing Metadata
Synthesis and Characterization of Specified
Impurities of Aceclofenac |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Synthesis and Characterization of Specified
Impurities of Aceclofenac |
| 2 | Creator | Author's name, affiliation, country | P. L. SOMASHEKAR*, P. N. SANJAY PAI and GOPALKRISHNA RAO
Department of Quality Assurance, Al-Ameen College of Pharmacy,
Near Lalbagh Main Gate, Hosur Road, Bangalore -560 027, India
Department of Pharmaceutical Chemistry, Goa College of Pharmacy,
18th June Road, Panaji, Goa- 403 001, India |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Aceclofenac, Impurity, Synthesis, Characterization |
| 4 | Description | Abstract | The present study aimed at synthesizing the process related potential impurities of aceclofenac. Aceclofenac is an orally administered phenyl acetic acid derivative with effects on a variety of inflammatory mediators. Process related impurities of aceclofenac listed in British Pharmacopoeia have been synthesized by modified methods and characterized by FT IR, MS and 1H NMR data. Impurity A: [2-[(2,6-dichlorophenyl)amino]phenyl]acetic acid (diclofenac) was synthesized by acid hydrolysis of diclofenac sodium; Impurity B: methyl [2-[(2,6-dichlorophenyl) amino] phenyl]acetate (methyl ester of diclofenac); Impurity C:Ethyl [2-[(2,6-dichlorophenyl) amino] phenyl]acetate (ethyl ester of diclofenac); Impurity D: methyl [[[2-[(2,6-dichlorophenyl) amino] phenyl] acetyl] oxy]acetate (methyl ester of aceclofenac) and Impurity E: ethyl [[[2-[(2,6-dichlorophenyl) amino]phenyl] acetyl] oxy]acetate (ethyl ester of aceclofenac) were sythesized by simple and convenient direct methylation and ethylation of diclofenac and aceclofenac respectively instead of tedious esterification process. Impurity F: benzyl [[[2-[(2,6-dichlorophenyl) amino] phenyl] acetyl] oxy] acetate (benzyl ester of aceclofenac) was synthesized by condensation of diclofenac sodium with benzylbromoacetate. Impurity I:1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indol-2-one was synthesized by acid cyclization of diclofenac. The present study has provided an efficient method for synthesis of process related aceclofenac impurities. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 2 , Number (3), (2013) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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