Indexing Metadata
Synthesis and Antimicrobial Activity of
Some Quinoxaline Derivatives |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Synthesis and Antimicrobial Activity of
Some Quinoxaline Derivatives |
| 2 | Creator | Author's name, affiliation, country | GAURI GUPTA, DHARMCHAND PRASAD SINGH and ARUN KUMAR MISHRA
College of Pharmacy, IFTM, Moradabad (U.P.), India
College of Pharmacy, SR group of Institutions, Jhansi (U.P.), India |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | 2-Hydroxy-3-methylquinoxaline, 3-Bromomethyl quinoxaline-2-one, p-Hydroxy bezaldehydes, 3-((4-(substituted-phenylimino)-methyl)-phenoxy)-methyl)quinoxalin-2(1H)-one, antimicrobial activity |
| 4 | Description | Abstract | A series of quinoxaline derivatives were synthesized by doing molecular modifications at C-3 methyl group of 2-hydroxy-3-methylquinoxaline nucleus. The synthesis was initiated by bromination followed by attachment of p-hydroxy bezaldehydes to 3-methyl group to synthesize 3(4-formyl phenoxymethyl)-quinoxaline-(1H)-2-one as new intermediate and condense it with substituted aromatic amines to afford the synthesis of Schiff bases of 3-methylquinoxalin-2(1H)-one. The new compounds (GG1, GG2, GG3, GG4 and GG5) have been synthesized by treating o-phenylene-diamine with ethyl pyruvate to yield
3-methylquinoxaline 2-one, which on bromination afforded the synthesis of 3-bromomethyl quinoxaline-2-one. Finally 3-bromomethyl quinoxaline-2-one was treated with 4-hydroxy benzaldehyde to yield the synthesis of 3-(-4-formyl phenoxy methyl)-quinoxalin 2(1H)-one (GG1), which was treated with different substituted aromatic amines to yield the synthesis of 3-((4-(substituted-phenylimino)-methyl)-phenoxy)-methyl)quinoxalin-2(1H)-one (GG2,GG3,GG4 and GG5). The structures of pure compounds were characterized on the basis of IR and 1H-NMR spectral analysis. All the synthesized compounds were evaluated for antimicrobial activity. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 2 , Number (4), (2013) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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