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Synthesis and Antimicrobial Activity of Some Quinoxaline Derivatives

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1TitleTitle of DocumentSynthesis and Antimicrobial Activity of Some Quinoxaline Derivatives
2CreatorAuthor's name, affiliation, country GAURI GUPTA, DHARMCHAND PRASAD SINGH and ARUN KUMAR MISHRA
College of Pharmacy, IFTM, Moradabad (U.P.), India
College of Pharmacy, SR group of Institutions, Jhansi (U.P.), India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords 2-Hydroxy-3-methylquinoxaline, 3-Bromomethyl quinoxaline-2-one, p-Hydroxy bezaldehydes, 3-((4-(substituted-phenylimino)-methyl)-phenoxy)-methyl)quinoxalin-2(1H)-one, antimicrobial activity
4DescriptionAbstract A series of quinoxaline derivatives were synthesized by doing molecular modifications at C-3 methyl group of 2-hydroxy-3-methylquinoxaline nucleus. The synthesis was initiated by bromination followed by attachment of p-hydroxy bezaldehydes to 3-methyl group to synthesize 3(4-formyl phenoxymethyl)-quinoxaline-(1H)-2-one as new intermediate and condense it with substituted aromatic amines to afford the synthesis of Schiff bases of 3-methylquinoxalin-2(1H)-one. The new compounds (GG1, GG2, GG3, GG4 and GG5) have been synthesized by treating o-phenylene-diamine with ethyl pyruvate to yield
3-methylquinoxaline 2-one, which on bromination afforded the synthesis of 3-bromomethyl quinoxaline-2-one. Finally 3-bromomethyl quinoxaline-2-one was treated with 4-hydroxy benzaldehyde to yield the synthesis of 3-(-4-formyl phenoxy methyl)-quinoxalin 2(1H)-one (GG1), which was treated with different substituted aromatic amines to yield the synthesis of 3-((4-(substituted-phenylimino)-methyl)-phenoxy)-methyl)quinoxalin-2(1H)-one (GG2,GG3,GG4 and GG5). The structures of pure compounds were characterized on the basis of IR and 1H-NMR spectral analysis. All the synthesized compounds were evaluated for antimicrobial activity.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2013.507
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (4), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
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