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Cytotoxic Activities of Newly Synthesized Co(II), Ni(II) and Cu(II) Complexes with Hexadentate Hydrazonic Ligands

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1TitleTitle of DocumentCytotoxic Activities of Newly Synthesized Co(II), Ni(II) and Cu(II) Complexes with Hexadentate Hydrazonic Ligands
2CreatorAuthor's name, affiliation, country WAEL HUSSEIN HEGAZY and MANAL HASSAN MARZOUK
Department of Chemistry, Faculty of Science, Suez University, Suez, 43533, Egypt
Clinical Biochemistry and Molecular Biology Unit, Cancer Biology Department, National Cancer Institute,
Cairo University, Cairo, 11553, Egypt
3SubjectDicipline(s) Chemical Science
3SubjectKeywords MCF-7, Nucleic acids, Antitumor activities, Transition metal complexes, Hexadentate hydrazonic ligands, Cytotoxicity
4DescriptionAbstract In this paper, we report the synthesis, characterization and antitumor studies of Co(II), Ni(II) and Cu(II) complexes with two potentially hexadentate ligands. Antitumor activity of the prepared ligands and its complexes against human breast cancer cell line MCF-7 was determined. The level of total protein, nucleic acids (RNA and DNA) and nitric oxide (NO) in MCF-7 treated cells was estimated. Antitumor activities of the complexes are accompanied with over-production of free and superoxide radicals allowed reactive oxygen species-mediated tumor cell death. The results show significant antitumor activity comparable to cisplatin
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2013.608
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  2 , Number  (4), (2013)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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