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Cytotoxic Activities of Newly Synthesized Co(II), Ni(II) and Cu(II) Complexes with Hexadentate Hydrazonic Ligands |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Cytotoxic Activities of Newly Synthesized Co(II), Ni(II) and Cu(II) Complexes with Hexadentate Hydrazonic Ligands |
| 2 | Creator | Author's name, affiliation, country | WAEL HUSSEIN HEGAZY and MANAL HASSAN MARZOUK
Department of Chemistry, Faculty of Science, Suez University, Suez, 43533, Egypt
Clinical Biochemistry and Molecular Biology Unit, Cancer Biology Department,
National Cancer Institute,
Cairo University, Cairo, 11553, Egypt |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | MCF-7, Nucleic acids, Antitumor activities, Transition metal complexes, Hexadentate hydrazonic ligands, Cytotoxicity |
| 4 | Description | Abstract | In this paper, we report the synthesis, characterization and antitumor studies of Co(II), Ni(II) and Cu(II) complexes with two potentially hexadentate ligands. Antitumor activity of the prepared ligands and its complexes against human breast cancer cell line MCF-7 was determined. The level of total protein, nucleic acids (RNA and DNA) and nitric oxide (NO) in MCF-7 treated cells was estimated. Antitumor activities of the complexes are accompanied with over-production of free and superoxide radicals allowed reactive oxygen species-mediated tumor cell death. The results show significant antitumor activity comparable to cisplatin |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 2 , Number (4), (2013) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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