Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
Home | Table of Contents | Submit an article | Subscribe | Login | Register

Indexing Metadata

Analysis of Oxidative Stress Parameters Depend on Diazepam Application in Rat Serum and Tissue Samples

DUBLINCOREMETADATA ITEM METADATA FOR THIS DOCUMENT
1TitleTitle of DocumentAnalysis of Oxidative Stress Parameters Depend on Diazepam Application in Rat Serum and Tissue Samples
2CreatorAuthor's name, affiliation, country ÖZNUR GÜNGÖR and NURHAYAT ÖZDEMIR
Department of Chemistry, Inonu University, Malatya-44280, Turkey
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Diazepam, Catalase activity, Malondialdehyde, Superoxide dismutase, Metabolism in rats
4DescriptionAbstract The aim of this study was to investigate the effect on antioxidant enzymes and malondialdehyde (MDA) in rat serum and various tissues of chronic diazepam application. Rats were exposed to diazepam intraperitonally twice a day for six weeks. The change in enzyme activity levels was determined. Diazepam was given in 1 mg/kg doses. In liver tissue, catalase (CAT) activity showed a significant decrease when diazepam group was compared to the control group (p <0.05). Superoxide dismutase (SOD) activity showed a significant increase in kidney tissue of diazepam group. GPx activity decreased in all tissues when diazepam group was compared to the control group. Although, changes in the level of MDA was not statistically significant in groups. These data indicate that chronic diazepam administration may cause to moderate oxidative stress conditions.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.616
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (1), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
Home | Table of Contents | Submit an article | Subscribe | Login | Register