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Synthesis and Antibacterial Activity of Some 1-Phenyl-3-aryl-5-(4-(3-propanoloxy) phenyl)-1H-pyrazoles

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1TitleTitle of DocumentSynthesis and Antibacterial Activity of Some 1-Phenyl-3-aryl-5-(4-(3-propanoloxy) phenyl)-1H-pyrazoles
2CreatorAuthor's name, affiliation, country ANJU GOYAL, NEELAM JAIN and SANDEEP JAIN
Chitkara College of Pharmacy, Rajpura, Patiala-140 401 (Punjab), India
Department of Pharmaceutical Education and Research, Bhagat Phool Singh Mahila Vishwavidyalaya,
Khanpur Kalan, Sonipat-131305 (Haryana), India
Drug Discovery and Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001 (Haryana), India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Chalcones, 1H-pyrazoles, Antibacterial activity, Minimum inhibitory concentration
4DescriptionAbstract A series of 1-phenyl-3-aryl-5-(4-(3-propanoloxy) phenyl)-1H-pyrazoles were synthesized from chalcones and studied for their in vitro antibacterial activity. Chalcones i.e.,1-aryl-3-(4-hydroxyphenyl) prop-2-en-1-ones (1) on reaction with phenyl hydrazine in presence of acetic acid and few drops of HCl yielded the corresponding 1-phenyl-3-aryl-5-(4-hydroxyphenyl)-1H-pyrazoles (2) which on further reaction with 3-chloropropanol furnished the title compounds (3). These compounds were characterized by CHN analyses, IR, mass and 1H NMR spectral data. All the compounds were evaluated for their in vitro antibacterial activity against two gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two gram positive strains (Bacillus subtilis and Staphylococcus aureus) and their minimum inhibitory concentration (MIC) were determined.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.664
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (1), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
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