Indexing Metadata
Stability-Indicating RP-HPLC Method for the
Determination of Valaciclovir Hydrochloride in
Bulk and Pharmaceutical Dosage Forms |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Stability-Indicating RP-HPLC Method for the
Determination of Valaciclovir Hydrochloride in
Bulk and Pharmaceutical Dosage Forms |
| 2 | Creator | Author's name, affiliation, country | DILLIP KUMAR SAHOO and PRAFULLA KUMAR SAHU
Department of Pharmaceutical Analysis, Avanthi Institute of Pharmaceutical Sciences, Cherukupally, Bhogapuram, Vizianagaram, Andhra Pradesh-531162, India
Department of Pharmaceutical Analysis, Raghu College of Pharmacy, Dakamarri, Bheemunipatnam, Visakhapatnam, Andhra Pradesh-531162, India |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Valaciclovir, Stability indicating, RPHPLC |
| 4 | Description | Abstract | A stability indicating reverse-phase HPLC method was developed for the determination of valaciclovir hydrochloride present in bulk and pharmaceutical dosage forms. The quantification was carried out using hypersil, ODS C18 (250×4.6 mm i.d., packed with 5 μ particle size) in an isocratic mode column with mobile phase comprising acetonitrile: phosphate buffer (pH- 3.6) in the ratio of 50:50 (%v/v). The flow rate was at 0.8 mL/min and detection was carried out at 252 nm. The retention time was 2.850 min for valaciclovir hydrochloride and the method produced linear response in the concentration range of 0.5 to 200 μg/mL (R2~0.9999). The recovery studies were also carried out and percent relative standard deviation from reproducibility was below 2%. The limit of detection and limit of quantification for this method were 0.110 μg/mL and 0.363 μg/mL, respectively. The proposed method was statistically evaluated and can be applied for routine quality control analysis of valaciclovir hydrochloride in Pharmaceutical dosage form. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 3 , Number (2), (2014) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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