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Synthesis of Various Esters of Diclofenac (NSAIDs) as Pro-Drugs and their Biological Evaluation

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1TitleTitle of DocumentSynthesis of Various Esters of Diclofenac (NSAIDs) as Pro-Drugs and their Biological Evaluation
2CreatorAuthor's name, affiliation, country S. B. SURYAWANSHI, HASSAN.A.OSMAN, Y.I.SHAIKH and G. M. NAZERUDDIN
Department of Chemistry (P.G. & Research Centre), Poona College of Arts, Science & Commerce, Pune, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Anti-inflammatory activity, Various esters of Diclofenac, Gastrointestinal irritation
4DescriptionAbstract Non-steroidal anti-inflammatory drugs (NSAIDs) commonly used for the treatment of chronic inflammatory diseases suffering from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The pro-drug designing is one of the several strategies used to overcome this drawback. The rationale behind the prodrug concept is to achieve temporary blockade of the free carboxylic group present in the NSAIDs till their systemic absorption. Five esters of diclofenac were synthesized with different alcohols and all the compounds were evaluated for anti-inflammatory activity by Carrageenan Induced Rat hand Paw method and surprisingly all of them showed quite appreciable anti-inflammatory activity.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.745
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (2), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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