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Spectrophotometric Methods for the Quantitative Estimation of Paliperidone in Formulations

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1TitleTitle of DocumentSpectrophotometric Methods for the Quantitative Estimation of Paliperidone in Formulations
2CreatorAuthor's name, affiliation, country UMAMAHESWAR KORRAPATI and RAMBABU CHINTALA*
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur, Andhra Pradesh, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Paliperidone, Spectrophotometric Methods, Isatin, Chloranilic acid
4DescriptionAbstract Two simple, sensitive and economical spectrophotometric methods have been developed and validated for the determination of paliperidone in pharmaceutical dosage forms. The methods were based on the formation of colored complex of Paliperidone with different reagents. The absorbance of the formed colored complex is measured at the wavelength of maximum absorbance of the complex 665 nm and 555 nm respectively against the reagent blank treated similarly. These methods have different linearity ranges observed in the concentration ranges of 1-6 and 10-60 μg/mL with correlation coefficient of 0.998 for both the methods. Statistical analysis indicates that the proposed methods are reproducible and selective for the estimation of Paliperidone in bulk drug and in its tablet dosage form.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.771
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (3), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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