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Simultaneous Estimation and Validation of Acelofenac and Paracetamol in Bulk and Tablets Using Mixed Hydrotropic Agents

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1TitleTitle of DocumentSimultaneous Estimation and Validation of Acelofenac and Paracetamol in Bulk and Tablets Using Mixed Hydrotropic Agents
2CreatorAuthor's name, affiliation, country GANESH PRASAD MISHRA, DEBADASH PANIGRAHI, HEMANT JOSHI and RAJESH MEENA
Ujjain Institute of Pharmaceutical Sciences, Chandesara, Dewas Road, Ujjain, Madhya Pradesh-456010, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Absorbance ratio method, Derivative method, Acelofenac, Paracetamol, Mixed hydrotropy
4DescriptionAbstract Two accurate, precise, sensitive and economical procedures for simultaneous determination of aceclofenac and paracetamol in tablet dosage form have been developed. In the present investigation, mixture of 20 mL (2 M) urea, 30 mL of (5 M) sodium acetate (hydrotropic solubilizing agent) was used to solubilize aceclofenac and paracetamol and carried out spectrophotometric analysis. The methods employed were absorbance ratio method (method I), derivative method (method II).The result showed that Beer’s law was obeyed in concentration range of 5-50 μg/mL with good linearity (r2?0.99) for both the drugs in both methods. The recoveries were within 99.67-101.33% for aceclofenac and 99.46-101.92% for paracetamol. Precision was good with acceptable limits of detection (LOD) and quantitation (LOQ) for both compounds. The optimized methods showed good reproducibility and recovery with standard deviation of < 1.0% and percent relative standard deviation less than 2.0%.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.790
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (2), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
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