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Synthesis and Antimicrobial Evaluation of Novel Azetidinones

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1TitleTitle of DocumentSynthesis and Antimicrobial Evaluation of Novel Azetidinones
2CreatorAuthor's name, affiliation, country SANJAY D. PRAJAPATI and M. K. THAKUR*
Department of Chemistry, Municipal Arts and Urban Science College, Mehsana-384002 (Guj.), India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords 3-(4-Aminophenylsulfonyl)-1,3,4-oxadiazole-2(3H)-thione, Schiff base, Azetidinone, Antibacterial activity.
4DescriptionAbstract 3-(4-Aminophenylsulfonyl)-1,3,4-oxadiazole-2(3H<)-thione (1) undergoes facile condensation with different aromatic aldehydes to afford the corresponding 3-(4-(substituted benzylideneamino)phenylsulfonyl)-1,3,4-oxadiazole-2(3H)-thione (2a-e) in good yields. Cyclocondensation of compounds (2a-e) with chloroacetyl chloride yields 3-chloro-4- subsituted phenyl-1-(4-(2-thioxo-1,3,4-oxadiazol-3(2H)-ylsulfonyl)phenyl)azetidin-2-one (3a-e). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.817
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (3), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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