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Development and Validation of a Stability-Indicating Liquid Chromatographic Method for the Assay of Cabazitaxel

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1TitleTitle of DocumentDevelopment and Validation of a Stability-Indicating Liquid Chromatographic Method for the Assay of Cabazitaxel
2CreatorAuthor's name, affiliation, country M. MATHRUSRI ANNAPURNA, B. VENKATESH, K. PRAMADVARA and S. HEMCHAND
Department of Pharmaceutical Analysis & Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India
Inogent Laboratories Pvt. Ltd., Hyderabad, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Cabazitaxel, RP-HPLC, Stability-indicating, ICH
4DescriptionAbstract A validated stability-indicating high-performance liquid chromatographic technique was developed for the determination of cabazitaxel. Chromatographic separation was performed on Shimadzu Model CBM-20A/20 Alite, using a mixture of sodium acetate buffer (pH 4.0) and acetonitrile (30:70, v/v) as mobile phase with a flow rate of 1.0 mL/min. Cabazitaxel was subjected to stress conditions (acidic, alkaline, oxidation photolytic and thermal degradations and the method was validated as per ICH guidelines.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.825
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (2), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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