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Development and Validation of a New Stability-Indicating Liquid Chromatographic Method for the Simultaneous Determination of Eprosartan and Hydrchlorothiazide in Tablets

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1TitleTitle of DocumentDevelopment and Validation of a New Stability-Indicating Liquid Chromatographic Method for the Simultaneous Determination of Eprosartan and Hydrchlorothiazide in Tablets
2CreatorAuthor's name, affiliation, country T. SRINIVASU, M. MATHRUSRI ANNAPURNA and T.G. CHANDRASHEKHAR
Department of Science and Technology, JNTU, Hyderabad, India
GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India
Ranbaxy Research Laboratories Ltd., Haryana, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Eprosartan, Hydrochlorothiazide, RP-HPLC, Stability-indicating, ICH
4DescriptionAbstract A validated stability-indicating high-performance liquid chromatographic method has been developed for the simultaneous determination of Eprosartan and hydrochlorothiazide in tablet dosage forms. Chromatographic separation was performed on HPLC system of waters Model 2997 using X Bridge Shield RP18 (150 x 3.0 mm i.d., 3.5 (μm particle size) column with a mixture of 0.1% formic acid and acetonitrile as mobile phase with a flow rate of 0.8 mL/min (gradient mode) with UV detection at 235 nm. The combinationof drugs was subjected to stress conditions such as acidic, alkaline, oxidation photolytic and thermal degradations and the method was validated as per ICH guidelines.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.827
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (2), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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