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Analytical Techniques for the Determination of Erlotinib HCl in Pharmaceutical Dosage Forms by Spectrophotometry

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1TitleTitle of DocumentAnalytical Techniques for the Determination of Erlotinib HCl in Pharmaceutical Dosage Forms by Spectrophotometry
2CreatorAuthor's name, affiliation, country M. MATHRUSRI ANNAPURNA, B. VENKATESH and R. KRISHNA CHAITANYA
Department of Pharmaceutical Analysis & Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Erlotinib HCl, Spectrophotometry, Validation
4DescriptionAbstract Three simple, rapid and sensitive spectrophotometric methods were developed for the determination of Erlotinib hydrochloride in pharmaceutical formulations. Beer’s law was obeyed over a concentration range 0.5-30 µg/mL in HCl and acetate buffer and 1-30 µg/mL in phosphate buffer. The linear regression equations were found to be y = 0.0717x + 0.0083, y = 0.0676x + 0.0102 and y = 0.0638x + 0.0096 in HCl, acetate buffer and phosphate buffer respectively and the three methods were validated as per ICH guidelines.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.828
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (2), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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