Indexing Metadata
Development and Validation of a Stability-Indicating
RP-HPLC Method for Analysis of Racecadotril in Pharmaceutical Dosage Forms |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Development and Validation of a Stability-Indicating
RP-HPLC Method for Analysis of Racecadotril in Pharmaceutical Dosage Forms |
| 2 | Creator | Author's name, affiliation, country | M. MATHRUSRI ANNAPURNA, A. NARENDRA and ALOK SAHU
Department of Pharmaceutical Analysis & Quality Assurance,
GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India
Micro Advanced Research Centre, MicroLabs Ltd., Bangalore, India
Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa, India |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Racecadotril, Stability indicating, RP-HPLC, ICH |
| 4 | Description | Abstract | A simple stability-indicating RP-HPLC method has been developed and validated for the determination of Racecadotril (RAC) in pharmaceutical dosage forms. The mobile phase consisting of methanol and tetra butyl ammonium hydrogen sulphate (80: 20, v/v) was used using isocratic elution with UV detection at 230 nm. The method showed good linearity for RAC in the 5-120 μg/mL range being the square of the correlation coefficient greater than 0.999. The limit of quantitation (LOQ) and limit of detection (LOD) were found to be 0.87527 and 0.28884 μg/mL respectively. The robustness was also evaluated by variations of mobile phase composition, flow rate and detection wavelength. The forced degradation kinetic study of Racecadotril by using HCl (0.1 M), NaOH (0.01 M), H2O2 (3%v/v), thermal (80 ±2 °C), hydrolysis and UV radiation (365 nm) were observed to be very specific. Finally the applicability of the method was evaluated in commercial dosage form analysis as well as in stability studies. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 3 , Number (2), (2014) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
|
