| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | A Validated Liquid Chromatographic Method for the Determination of Solifenacin Succinate (Urinary Antispasmodic) in Tablets |
| 2 | Creator | Author's name, affiliation, country | M. MATHRUSRI ANNAPURNA, G. SOWJANYA,
M. SANTOSH NAIDU and D. LOHITHASU
GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | RP-HPLC, Solifenacin succinate, Validation, Tablets |
| 4 | Description | Abstract | An isocratic reversed-phase liquid chromatographic method was developed and validated for the determination of Solifenacin succinate. Chromatographic separation was achieved on a C18 column using an aqueous tetra butyl ammonium hydrogen sulphate (10 mM): acetonitrile (40:60, v/v), with flow rate
0.8 mL/min (UV detection at 254 nm). Linearity was observed in the concentration range of 20-200 µg/mL (R2= 0.999). The limit of quantitation was found to be 0.845 µg/mL and the limit of detection was found to be 0.0269 µg/mL. The method was validated as per ICH guidelines. The method is simple, precise, robust and accurate for the determination of Solifenacin in tablet dosage forms. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 3 , Number (2), (2014) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
