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A Validated Liquid Chromatographic Method for the Determination of Solifenacin Succinate (Urinary Antispasmodic) in Tablets

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1TitleTitle of DocumentA Validated Liquid Chromatographic Method for the Determination of Solifenacin Succinate (Urinary Antispasmodic) in Tablets
2CreatorAuthor's name, affiliation, country M. MATHRUSRI ANNAPURNA, G. SOWJANYA, M. SANTOSH NAIDU and D. LOHITHASU
GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords RP-HPLC, Solifenacin succinate, Validation, Tablets
4DescriptionAbstract An isocratic reversed-phase liquid chromatographic method was developed and validated for the determination of Solifenacin succinate. Chromatographic separation was achieved on a C18 column using an aqueous tetra butyl ammonium hydrogen sulphate (10 mM): acetonitrile (40:60, v/v), with flow rate
0.8 mL/min (UV detection at 254 nm). Linearity was observed in the concentration range of 20-200 µg/mL (R2= 0.999). The limit of quantitation was found to be 0.845 µg/mL and the limit of detection was found to be 0.0269 µg/mL. The method was validated as per ICH guidelines. The method is simple, precise, robust and accurate for the determination of Solifenacin in tablet dosage forms.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.831
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (2), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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