Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
Home | Table of Contents | Submit an article | Subscribe | Login | Register

Indexing Metadata

Microwave Assisted Synthesis, Molecular Docking and HIV-1 gp120 CD4 Binding Inhibition Studies of Symmetrical N, N'-disubstituted Urea/Thiourea

DUBLINCOREMETADATA ITEM METADATA FOR THIS DOCUMENT
1TitleTitle of DocumentMicrowave Assisted Synthesis, Molecular Docking and HIV-1 gp120 CD4 Binding Inhibition Studies of Symmetrical N, N'-disubstituted Urea/Thiourea
2CreatorAuthor's name, affiliation, country SREE KANTH SIVAN, RADHIKA VANGALA and VIJJULATHA MANGA*
Molecular Modeling and Medicinal Chemistry Group, Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Disubstituted ureas, Amine hydrochlorides, Microwave irradiation, HIV-1 gp120, Docking
4DescriptionAbstract An effective and eco friendly procedure under microwave irradiation, for synthesis of symmetrical disubstituted alkyl and aryl ureas from amine hydrochlorides using water as solvent medium has been developed. Based on molecular docking studies on HIV-1 gp120, synthesized compounds were evaluated for HIV-1 gp120 CD4 binding inhibition and these molecules showed micro molar range (0.047 μM to 4.07 μM) of inhibition.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.890
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (4), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
Home | Table of Contents | Submit an article | Subscribe | Login | Register