Indexing Metadata
Microwave Assisted Synthesis, Molecular Docking and HIV-1 gp120 – CD4 Binding Inhibition Studies of Symmetrical
N, N'-disubstituted Urea/Thiourea |
| DUBLIN | CORE | METADATA ITEM | METADATA FOR THIS DOCUMENT |
| 1 | Title | Title of Document | Microwave Assisted Synthesis, Molecular Docking and HIV-1 gp120 – CD4 Binding Inhibition Studies of Symmetrical
N, N'-disubstituted Urea/Thiourea |
| 2 | Creator | Author's name, affiliation, country | SREE KANTH SIVAN, RADHIKA VANGALA and VIJJULATHA MANGA*
Molecular Modeling and Medicinal Chemistry Group, Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India |
| 3 | Subject | Dicipline(s) | Chemical Science |
| 3 | Subject | Keywords | Disubstituted ureas, Amine hydrochlorides, Microwave irradiation, HIV-1 gp120, Docking |
| 4 | Description | Abstract | An effective and eco friendly procedure under microwave irradiation, for synthesis of symmetrical disubstituted alkyl and aryl ureas from amine hydrochlorides using water as solvent medium has been developed. Based on molecular docking studies on HIV-1 gp120, synthesized compounds were evaluated for HIV-1 gp120 – CD4 binding inhibition and these molecules showed micro molar range (0.047 μM to 4.07 μM) of inhibition. |
| 5 | Publishers | Organizing agency, location | WWW Publications, India |
| 6 | Contributor | Sponsor(s) | - |
| 7 | Date | Date (YYYY-MM-DD) | - |
| 8 | Type | Status & genre | Peer-reviewed Article |
| 8 | Type | Type | |
| 9 | Formate | File Formate | PDF |
| 10 | Identifier | Uniform Resource Identifier | Click Here |
| 10 | Identifier | Digital Object Identifier | |
| 11 | Source | Journal/conference title; vol., no. (Year) | Chemical Science Transactions, Volume 3 , Number (4), (2014) |
| 12 | Lanuguage | English=en | en |
| 13 | Relation | Supp.files | |
| 14 | Coverage | | - |
| 15 | Copyright | Copyright and permissions | |
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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