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Extractive Spectroscopic Determination of Lansoprazole in Pharmaceutical Dosage Form

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1TitleTitle of DocumentExtractive Spectroscopic Determination of Lansoprazole in Pharmaceutical Dosage Form
2CreatorAuthor's name, affiliation, country IFFATH RIZWANA, K. VANITHA PRAKASH* and G. KRISHNA MOHAN
Research and Development, JNTU-K, Kakinada, A.P. India and Deccan School of Pharmacy, Hyderabad, AP, India
Department of Pharmaceutical Analysis, SSJ College of Pharmacy, Gandipet, Hyderabad, A.P. India
Centre for Pharmaceutical Sciences, IST, JNTU Hyderabad, A.P. India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Extractive spectrophotometric, Lansoprazole, Metanil Yellow, Methyl Orange.
4DescriptionAbstract Two simple and sensitive extractive spectrophotometric methods have been described for the assay of Lansoprazole (LPZ) either in pure form or in pharmaceutical formulations. The methods were based on the formation of ion-pair complex between LPZ and Metanil Yellow (MY) Method- A and methyl orange (MO)- Method- B, at pH 2.5 has been described. The formed complex were extracted quantitatively into chloroform and measured at 440 nm and 450 nm with MY and MO respectively. Beer's law was obeyed in the concentration range of 20-70 µg mL-1 and 6-16 µg mL-1 with molar absorptivity of 1.329 x 10-8 and 1.822 x 10-8 L mol-1 cm-1 with MY and MO respectively. Statistical comparison of the results of the proposed method with those of the reference method shows excellent agreement and indicates no significant difference in accuracy and precision. The limits of detection and quantification have been determined for two methods. Both the methods have been validated as per the guidelines of ICH. The methods have been applied to the determination of drug in commercial capsules and results of analysis were validated statistically through recovery studies.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2014.933
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  3 , Number  (4), (2014)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
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