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Synthesis and Antibacterial Activity of 2-(Substituted phenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazoles

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1TitleTitle of DocumentSynthesis and Antibacterial Activity of 2-(Substituted phenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazoles
2CreatorAuthor's name, affiliation, country I. SINGH1* and A. KUMAR2
1Department of Chemistry, J.V College Baraut (Baghpat) U.P., 250611, India
2Department of Community Medicine, LLRM Medical College, Meerut U.P., 250004, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords Pyridine, Oxadiazole, Antibacterial activity
4DescriptionAbstract Ethyl pyridine-4-carboxylate (1) treated with hydrazine hydrate in methanol give pyridine-4-carboxy hydrazide (2). Compound 2 react with substituted aroyl chlorides affords N-substituted aroyl pyridine-4-carbonyl hydrazines (3-9), which on treatment with POCl3 yield 2(substituted phenyl)-5-(pyridine-4-yl)-1,3,4-oxadiazoles (10-16). The newly synthesized compounds 10-16 were confirmed by elemental (C, H, N) and spectral (IR, 1H NMR and mass) analysis. Compounds 10-16 have been tested for their antibacterial activity using ampicillin as a reference compound.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2015.941
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  4 , Number  (1), (2015)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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