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Green and Efficient Microwave One-Pot Synthetic Approach to 2-N-Methylpiperazino-5-mercapto-substituted Aryl-1,3,4-oxadiazole Derivatives and Evaluation of their In vitro Antioxidant and Anti-inflammatory Activity

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1TitleTitle of DocumentGreen and Efficient Microwave One-Pot Synthetic Approach to 2-N-Methylpiperazino-5-mercapto-substituted Aryl-1,3,4-oxadiazole Derivatives and Evaluation of their In vitro Antioxidant and Anti-inflammatory Activity
2CreatorAuthor's name, affiliation, country NEETU BHARATIY* and CHANDRA PRAKASH GHARU
Department of Chemistry, Government College, Merta City, Nagaur, Rajasthan, India
3SubjectDicipline(s) Chemical Science
3SubjectKeywords 1,3,4-Oxadiazole, Anti-inflammatory, Antioxidant, N-Methylpiperazine, Green synthesis
4DescriptionAbstract An efficient one pot sequential protocol has been developed for synthesis of 2-N-methyl-piperazino-5-mercapto-aryl substituted-1,3,4-oxadiazoles. Synthesized compounds were characterized by FTIR, 1H NMR and elemental analysis. Antioxidant activity of methanol solutions of synthesized compounds was determined by reducing power assay and hydrogen peroxide scavenging activity at 700 nm and 250 nm respectively. The synthesized compounds were also screened for anti-inflammatory activity. Compound showed good anti-inflammatory and antioxidant activities.
5PublishersOrganizing agency, location WWW Publications, India
6Contributor Sponsor(s) -
7DateDate (YYYY-MM-DD) -
8TypeStatus & genre Peer-reviewed Article
8TypeType
9FormateFile Formate PDF
10IdentifierUniform Resource Identifier Click Here
10IdentifierDigital Object Identifier DOI:10.7598/cst2015.973
11SourceJournal/conference title; vol., no. (Year)Chemical Science Transactions, Volume  4 , Number  (1), (2015)
12LanuguageEnglish=en en
13RelationSupp.files
14Coverage -
15CopyrightCopyright and permissions
Chemical Science Transactions | Chem Sci Trans | CST | Online Chemistry Journal | Open Access
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