Chem Sci Trans., 2019, 8(3),  pp 308- 317  
DOI:10.7598/cst2019.1455

Research Article

Design, Synthesis and Biological Evaluation of 3-n-Butylphthlide-Edaravone Hybrids as Potential Agents for the Treatment of Cerebral Ischemia

XIA-MIN HU^1,2, WEI DONG¹ , QIAN ZHANG¹ , QIONG YUAN^{1, 3, 4}, ZHI-WEN CUI¹, CHENG-ZHI GAO¹, ZHI-JUN YU¹ and ZHEN-LI MIN^{1, 3, 4} *

¹ Department of Pharmacy, College of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei Province 430065, China
² College of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
³ Drug Research Base of Cardiovascular and Cerebral Vascular, College of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei Province 430065, China
⁴ New Drugs Innovation and Development institute, Department of Pharmacy, College of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei Province 430065, China