Research Article
Synthesis and Characterization of New Diketone Analogues of Podophyllotoxin
K. H. HEMAKUMAR*, A. D. SATHISHA and Y. B. BASAVARAJU
ABSTRACT
The new compounds 6,6a-dihydro-2,3-dimethoxy-9-nitro–11bH benzo [C]-fluoren 5,7-dione, 6,6a-dihydro-2,3-dimethoxy-9-chloro–11bH benzo[C]-fluoren-5,7-dione and 6,6a-dihydro-2,3-dimethoxy-9-fluoro–11bH benzo[C]-fluoren-5,7- dione were synthesized in high yields. They are analogues of naturally occurring lignan podophyllotoxin which exhibits anticancer activity. They are very essential to study anticancer activity.
Received 2 June 2007; Accepted 13 July 2007