E-Journal of Chemistry

Research Article

E-J.Chem , Volume 5, Number 3, p 562-566

Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities

SINGAMSETTY RADHA KRISHNA, MANDAVA VENKATA NAGA BRAHMESHWAR RAO, TIRMALARAJU SATYANARYANA RAJU, VURIMIDI HIMABINDU and GHANTA MAHESH REDDY

Research and Development, Dr. Reddy's Laboratories Ltd., Integrated Product and Development, Unit-III, Plot No. 116, S V Co-Op. Ind. Estate, Bollaram, Jinnaram, Medak Dist 502 325; A P, India
Institute of Sciences and Technology, Center for Environmental Sciences, J.N.T. University, Kukatpally, Hyderabad-500072, India
Dr. Reddy’s communication No. DRL-IPDO-IPM - 00074

ABSTRACT

Three unknown impurities in rosiglitazone maleate 1 bulk drug at level below 0.1% (ranging from 0.05 to 0.1%) were detected by simple reverse phase high performance liquid chromatography. These impurities were preliminarily identified with LC-MS and characterized by the mass number of the impurities. Different experiments were conducted and finally synthesized and characterized the unknown impurities..

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Received15 November 2007; Accepted 2 January 2008

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