E-Journal of Chemistry

Research Article

E-J.Chem , Volume 5, Number 3, p 641-647

A Simple and Mild Acylation of Alcohols, Phenols, Amines, and Thiols with a Reusable Heteropoly Acid Catalyst
(H₆P₂W₁₈O₆₂.24 H₂O)

Centro de Investigación y Desarrollo en Ciencias Aplicadas (CINDECA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata-CONICET.
Calle 47 No 257, B1900JK La Plata, Argentina
Catedra de Quimica Organica, Facultad de Ciencias Agrarias y Forestales, UNLP. Calles 60 y 119, B1904AAN La Plata, Argentina
Departamento de Ingenieria Quimica, Facultad de Ingenieria, Universidad de Buenos Aires. Ciudad Universitaria, C1428BGA Buenos Aires, Argentina

ABSTRACT

The acylation of alcohols, phenols, thiols, and amines with varied substitution using acid anhydrides is efficiently catalyzed by Wells-Dawson heteropoly acid (H₆P₂W₁₈O₆₂.24 H₂O). Reactions proceed with very good to excellent yield in air at room temperature, using toluene as solvent (40 examples). The bulk catalyst was easily reused without appreciable loss of its activity.

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